Opportunity Information: Apply for PAR 20 030
The NIH funding opportunity PAR 20-030, titled "HIV-associated Non-Communicable Diseases Research at Low- and Middle-Income Country Institutions (R21 Clinical Trial Optional)," supports exploratory, locally relevant research on the growing burden of non-communicable diseases (NCDs) among people living with HIV in low- and middle-income countries (LMICs). Using the NIH R21 mechanism, it is geared toward early-stage or proof-of-concept projects that can generate key preliminary data, test feasibility of new ideas, and open up future, larger lines of investigation. A central theme is strengthening research capacity within LMIC institutions and building a durable network of investigators across LMIC settings, rather than treating LMIC sites only as places to collect data.
The scientific focus is the intersection between HIV and NCDs, especially how HIV infection and its long-term management may affect the development, underlying biology (etiopathogenesis), detection, prevention, treatment, and integrated care of chronic comorbid conditions. The opportunity explicitly encourages studies that dig into the mechanisms by which HIV might shape NCD risk and progression, as well as pragmatic work to identify appropriate strategies for diagnosis and prevention and to improve therapeutic interventions and integrated clinical care models for people managing both HIV and chronic diseases. Clinical trials are allowed but not required, which gives applicants flexibility to propose observational, implementation-oriented, or mechanistic studies, or small clinical studies when justified.
Projects are expected to align with NIH HIV/AIDS Research Priorities, meaning proposals should be framed to address high-impact questions in HIV research that are consistent with NIH-wide priorities (the notice referenced in the opportunity). Research teams are expected to be genuinely interdisciplinary, bringing together HIV expertise and NCD expertise in a way that supports new joint approaches. The program emphasizes partnerships that can generate novel ideas, evaluate feasibility, and ultimately reduce long-term illness and disability associated with HIV-NCD comorbidity.
A defining feature of this announcement is its LMIC-centered structure. Research is intended to be conducted at LMIC sites, and the program asks applicants to directly address the capacity needs of collaborating LMIC institutions. In practice, that means applications should not only propose a scientific study but also describe how the collaboration will strengthen local ability to conduct HIV-NCD research, such as through training, infrastructure development, mentorship, data systems, regulatory/ethics support, or other sustainable enhancements that outlast the single project.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations, such as universities, nonprofits, for-profits (other than small businesses), small businesses, and multiple levels of government entities. The announcement also calls out additional eligible applicants including foreign organizations, regional organizations, community- and faith-based organizations, HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and U.S. territories or possessions. LMIC status is determined using the World Bank country income classification (low-income, lower-middle-income, and upper-middle-income) based on GNI per capita.
The collaboration model requires a linked U.S.-LMIC partnership when U.S. investigators are involved: a U.S. investigator must apply together with an LMIC investigator for collaborative projects carried out at LMIC sites. This structure is meant to ensure shared leadership and meaningful engagement with LMIC institutions, and to support both scientific outcomes and local capacity development.
From an administrative standpoint, the opportunity is a discretionary NIH grant using the R21 funding instrument. The listed award ceiling is $150,000, reflecting the smaller, exploratory nature of R21 projects. The original closing date shown in the source information is 2020-12-03, and the funding opportunity is associated with multiple CFDA numbers tied to NIH health research programs. Overall, the program is best suited for teams proposing focused, innovative studies that clarify how HIV and chronic diseases interact in LMIC contexts while simultaneously strengthening local research ecosystems and cross-country collaboration.Apply for PAR 20 030
- The National Institutes of Health in the education, food and nutrition, health sector is offering a public funding opportunity titled "HIV-associated Non-Communicable Diseases Research at Low- and Middle-Income Country Institutions (R21 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.393, 93.394, 93.395, 93.396, 93.399, 93.847, 93.989.
- This funding opportunity was created on 2019-10-18.
- Applicants must submit their applications by 2020-12-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the NIH funding opportunity PAR 20-030 about?
PAR 20-030, titled "HIV-associated Non-Communicable Diseases Research at Low- and Middle-Income Country Institutions (R21 Clinical Trial Optional)," supports exploratory research on the growing burden of non-communicable diseases (NCDs) among people living with HIV in low- and middle-income countries (LMICs). It emphasizes locally relevant science conducted at LMIC institutions and building long-term research capacity and investigator networks within LMIC settings.
What grant mechanism does this opportunity use?
This opportunity uses the NIH R21 mechanism, which is intended for early-stage, exploratory, or proof-of-concept projects. R21 projects are commonly used to generate key preliminary data, test feasibility, and open the door to future, larger studies.
What is the main scientific focus of PAR 20-030?
The focus is the intersection of HIV and non-communicable diseases, including how HIV infection and long-term HIV management may influence the development, biology (etiopathogenesis), detection, prevention, treatment, and integrated care of chronic comorbid conditions.
What kinds of research topics are encouraged under this announcement?
The announcement encourages both mechanistic and pragmatic research, including studies that examine mechanisms by which HIV might shape NCD risk and progression, and studies that identify strategies for diagnosis and prevention or improve therapeutic interventions and integrated care models for people managing both HIV and chronic diseases.
Are clinical trials required for this R21 opportunity?
No. Clinical trials are allowed but not required. Applicants may propose observational studies, implementation-oriented work, mechanistic studies, or small clinical studies when justified.
Where is the research expected to be conducted?
Research is intended to be conducted at LMIC sites. A defining feature of the announcement is its LMIC-centered structure, which aims to avoid treating LMIC sites only as locations for data collection and instead strengthens LMIC institutions as research leaders and partners.
How is LMIC status defined for this opportunity?
LMIC status is determined using the World Bank country income classification based on GNI per capita, including low-income, lower-middle-income, and upper-middle-income countries.
Does this opportunity emphasize research capacity building in LMIC institutions?
Yes. Applications are expected to address the capacity needs of collaborating LMIC institutions and describe how the project and partnership will strengthen local ability to conduct HIV-NCD research in a sustainable way.
What are examples of LMIC research capacity strengthening activities mentioned in the announcement?
Examples include training, infrastructure development, mentorship, building data systems, strengthening regulatory and ethics support, and other sustainable enhancements that can outlast the single project.
Does the opportunity require interdisciplinary research teams?
Yes. Teams are expected to be genuinely interdisciplinary, combining HIV expertise and NCD expertise in ways that support new joint approaches to HIV-NCD comorbidity research and care.
How should proposed projects align with NIH priorities?
Projects are expected to align with NIH HIV/AIDS Research Priorities. Proposals should be framed to address high-impact HIV research questions consistent with NIH-wide priorities referenced by the funding opportunity.
What is meant by an "LMIC-centered" collaboration model?
It means the research is designed to be locally relevant and carried out at LMIC institutions, with explicit attention to strengthening those institutions and creating a durable network of investigators across LMIC settings.
Is a U.S.-LMIC partnership required?
When U.S. investigators are involved, the model requires a linked U.S.-LMIC partnership: a U.S. investigator must apply together with an LMIC investigator for collaborative projects carried out at LMIC sites. This is intended to ensure shared leadership and meaningful LMIC engagement.
Who is eligible to apply for this funding opportunity?
Eligibility is broad and includes many types of U.S. and non-U.S. organizations such as universities, nonprofits, for-profits (other than small businesses), small businesses, and government entities at multiple levels. The announcement also lists foreign organizations, regional organizations, community- and faith-based organizations, HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and U.S. territories or possessions among eligible applicants.
What types of organizations are explicitly mentioned as eligible?
The announcement explicitly calls out (among others) foreign organizations, regional organizations, community- and faith-based organizations, HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and organizations in U.S. territories or possessions.
What is the award ceiling for PAR 20-030?
The listed award ceiling is $150,000, reflecting the smaller and exploratory nature of R21 projects.
What is the purpose of using the R21 mechanism for this topic area?
The R21 format fits projects that are focused and innovative, such as feasibility testing, proof-of-concept studies, and preliminary data generation related to HIV-NCD interactions and integrated approaches to care in LMIC contexts.
Does this opportunity support implementation-oriented or integrated care model research?
Yes. The opportunity highlights pragmatic work to improve diagnosis, prevention, treatment approaches, and integrated clinical care models for people living with HIV who also have chronic non-communicable diseases.
What overall outcomes is the program trying to achieve?
The program aims to generate novel ideas and feasibility evidence, clarify how HIV and chronic diseases interact in LMIC settings, improve interventions and integrated care approaches, reduce long-term illness and disability related to HIV-NCD comorbidity, and strengthen sustainable research ecosystems and networks in LMIC institutions.
What is the listed closing date in the source information?
The original closing date shown in the provided source information is 2020-12-03.
Is this a discretionary NIH grant?
Yes. From an administrative standpoint, the opportunity is described as a discretionary NIH grant using the R21 funding instrument.
Are CFDA numbers associated with this opportunity?
Yes. The opportunity is associated with multiple CFDA numbers tied to NIH health research programs (specific CFDA numbers are not listed in the provided information).
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