HIV-Focused Population Surveys in Countries Supported Under the President's Emergency Plan for AIDS Relief (PEPFAR) | CDC RFA GH19 1941

Opportunity Information: Apply for CDC RFA GH19 1941

The grant opportunity titled "HIV-Focused Population Surveys in Countries Supported Under the President's Emergency Plan for AIDS Relief (PEPFAR)" (Funding Opportunity Number: CDC RFA GH19 1941) is a CDC-led cooperative agreement designed to fund and support large, HIV-focused population surveys in countries where PEPFAR operates. Its main goal is to generate reliable, nationally and subnationally representative, household-based data on HIV across general populations of all ages, with most of the work expected to occur in sub-Saharan Africa. A secondary goal is to support HIV-focused surveys that also include size estimation and related measurements for key and priority populations in PEPFAR-supported settings, helping countries better understand groups that may be undercounted or underserved in routine systems.

At its core, this opportunity supports surveys that measure the real-world impact of HIV programs and provide evidence that governments and partners can use to adjust strategies at both national and local levels. The surveys are intended to go beyond basic case counts by directly estimating HIV prevalence and incidence and by collecting laboratory and interview information that reflects how well prevention and treatment services are reaching people. This includes measuring viral load (to understand viral suppression at the population level), drug resistance and other relevant biomarkers, and indicators tied to service uptake and coverage. A major analytic purpose is tracking progress toward the UNAIDS 95-95-95 targets, meaning the proportion of people living with HIV who know their status, the proportion of those diagnosed who are on treatment, and the proportion of those on treatment who are virally suppressed. Because these targets are population-level goals, household surveys provide an independent way to validate and complement routine program data.

The opportunity also allows for the integration of related health measurements that are closely connected to HIV outcomes and public health planning. In addition to HIV-specific testing and biomarkers, the surveys may include measurements for conditions such as tuberculosis, hepatitis, and syphilis, where combining surveillance efforts can strengthen public health action and improve efficiency. By collecting these data in a standardized survey framework, countries can better interpret co-infection burdens, identify overlapping risk patterns, and plan integrated service delivery rather than treating each condition in isolation.

A key emphasis of the NOFO is quality, comparability, and long-term utility of the data. The CDC intends these surveys to use standardized methods for both interviews and laboratory work, producing high-quality datasets that can be compared across time and, where appropriate, across countries and regions. The NOFO explicitly aims to strengthen local survey capacity, meaning that the work is not only about producing one-time estimates but also about building the systems and expertise needed to plan, implement, and analyze high-quality population surveys in-country. Another major priority is ensuring that resulting data are publicly accessible, supporting transparency and enabling broader scientific and programmatic use to improve HIV responses. The NOFO also highlights the creation of specimen repositories, which can allow for future testing and research as new questions emerge, new assays become available, or additional validation is needed.

From an administrative standpoint, this is a discretionary funding opportunity using a cooperative agreement mechanism, which typically means the CDC anticipates substantial involvement through technical assistance and collaboration rather than simply issuing funds with minimal engagement. The activity category is health, and it falls under CFDA 93.067. Eligibility is broadly unrestricted (open to any type of entity, subject to any additional eligibility language in the full announcement). The award ceiling is listed as $75,000,000, and the CDC expected to make four awards. The opportunity was created on June 14, 2018, with an original closing date of August 14, 2018, and applications were required to be submitted electronically by 11:59 p.m. Eastern Time on the due date. Overall, the opportunity is structured to produce decision-ready HIV surveillance evidence, improve country capacity to generate that evidence, and make both data and specimens available in ways that can continue to strengthen HIV programs over time.

• The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "HIV-Focused Population Surveys in Countries Supported Under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
• This funding opportunity was created on Jun 14, 2018.
• Applicants must submit their applications by Aug 14, 2018 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $75,000,000.00 in funding.
• The number of recipients for this funding is limited to 4 candidate(s).
• Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.

Apply for CDC RFA GH19 1941

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