Opportunity Information: Apply for CDC RFA GH19 1941
The grant opportunity titled "HIV-Focused Population Surveys in Countries Supported Under the President's Emergency Plan for AIDS Relief (PEPFAR)" (Funding Opportunity Number: CDC RFA GH19 1941) is a CDC-led cooperative agreement designed to fund and support large, HIV-focused population surveys in countries where PEPFAR operates. Its main goal is to generate reliable, nationally and subnationally representative, household-based data on HIV across general populations of all ages, with most of the work expected to occur in sub-Saharan Africa. A secondary goal is to support HIV-focused surveys that also include size estimation and related measurements for key and priority populations in PEPFAR-supported settings, helping countries better understand groups that may be undercounted or underserved in routine systems.
At its core, this opportunity supports surveys that measure the real-world impact of HIV programs and provide evidence that governments and partners can use to adjust strategies at both national and local levels. The surveys are intended to go beyond basic case counts by directly estimating HIV prevalence and incidence and by collecting laboratory and interview information that reflects how well prevention and treatment services are reaching people. This includes measuring viral load (to understand viral suppression at the population level), drug resistance and other relevant biomarkers, and indicators tied to service uptake and coverage. A major analytic purpose is tracking progress toward the UNAIDS 95-95-95 targets, meaning the proportion of people living with HIV who know their status, the proportion of those diagnosed who are on treatment, and the proportion of those on treatment who are virally suppressed. Because these targets are population-level goals, household surveys provide an independent way to validate and complement routine program data.
The opportunity also allows for the integration of related health measurements that are closely connected to HIV outcomes and public health planning. In addition to HIV-specific testing and biomarkers, the surveys may include measurements for conditions such as tuberculosis, hepatitis, and syphilis, where combining surveillance efforts can strengthen public health action and improve efficiency. By collecting these data in a standardized survey framework, countries can better interpret co-infection burdens, identify overlapping risk patterns, and plan integrated service delivery rather than treating each condition in isolation.
A key emphasis of the NOFO is quality, comparability, and long-term utility of the data. The CDC intends these surveys to use standardized methods for both interviews and laboratory work, producing high-quality datasets that can be compared across time and, where appropriate, across countries and regions. The NOFO explicitly aims to strengthen local survey capacity, meaning that the work is not only about producing one-time estimates but also about building the systems and expertise needed to plan, implement, and analyze high-quality population surveys in-country. Another major priority is ensuring that resulting data are publicly accessible, supporting transparency and enabling broader scientific and programmatic use to improve HIV responses. The NOFO also highlights the creation of specimen repositories, which can allow for future testing and research as new questions emerge, new assays become available, or additional validation is needed.
From an administrative standpoint, this is a discretionary funding opportunity using a cooperative agreement mechanism, which typically means the CDC anticipates substantial involvement through technical assistance and collaboration rather than simply issuing funds with minimal engagement. The activity category is health, and it falls under CFDA 93.067. Eligibility is broadly unrestricted (open to any type of entity, subject to any additional eligibility language in the full announcement). The award ceiling is listed as $75,000,000, and the CDC expected to make four awards. The opportunity was created on June 14, 2018, with an original closing date of August 14, 2018, and applications were required to be submitted electronically by 11:59 p.m. Eastern Time on the due date. Overall, the opportunity is structured to produce decision-ready HIV surveillance evidence, improve country capacity to generate that evidence, and make both data and specimens available in ways that can continue to strengthen HIV programs over time.Apply for CDC RFA GH19 1941
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "HIV-Focused Population Surveys in Countries Supported Under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Jun 14, 2018.
- Applicants must submit their applications by Aug 14, 2018 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $75,000,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "HIV-Focused Population Surveys in Countries Supported Under the President's Emergency Plan for AIDS Relief (PEPFAR)."
What is the Funding Opportunity Number (NOFO/RFA number)?
The Funding Opportunity Number is CDC RFA GH19 1941.
Which federal agency is leading this opportunity?
The opportunity is led by the Centers for Disease Control and Prevention (CDC).
What type of funding mechanism is being used?
This is a cooperative agreement, which typically means CDC expects substantial involvement, including technical assistance and collaboration, rather than a hands-off grant.
Is this a discretionary or mandatory funding opportunity?
This is a discretionary funding opportunity.
What is the main purpose of the award?
The primary goal is to fund and support large, HIV-focused population surveys in countries where PEPFAR operates, producing reliable nationally and subnationally representative, household-based HIV data across general populations of all ages.
Where is most of the work expected to take place?
Most of the work is expected to occur in sub-Saharan Africa, in countries supported under PEPFAR.
What kinds of surveys are being supported?
The opportunity supports large, household-based population surveys designed to generate nationally and subnationally representative estimates related to HIV and HIV program impact.
What does "population-based, household survey" mean in this context?
In this context, it refers to surveys conducted in households (rather than only clinics or program sites) to generate representative estimates for the general population, enabling independent measurement of HIV indicators beyond routine program reporting.
What is the secondary goal of the opportunity?
A secondary goal is to support HIV-focused surveys that also include size estimation and related measurements for key and priority populations in PEPFAR-supported settings, to help countries better understand populations that may be undercounted or underserved in routine systems.
What is meant by "key and priority populations" in the description?
The opportunity describes key and priority populations as groups that may be undercounted or underserved in routine systems and for whom size estimation and related measurements can improve understanding and planning in PEPFAR-supported settings.
What kinds of HIV outcomes and indicators are these surveys expected to measure?
The surveys are intended to estimate HIV prevalence and incidence and to collect interview and laboratory information reflecting prevention and treatment reach. This includes viral load measurement (to assess population-level viral suppression), drug resistance, other relevant biomarkers, and indicators tied to service uptake and coverage.
How do these surveys help measure the real-world impact of HIV programs?
They provide independent, population-level evidence on HIV burden and service reach (including viral suppression and other biomarkers) that governments and partners can use to adjust strategies at national and local levels, going beyond basic case counts.
How does this opportunity relate to the UNAIDS 95-95-95 targets?
A major analytic purpose is tracking progress toward 95-95-95: the proportion of people living with HIV who know their status, the proportion of those diagnosed who are on treatment, and the proportion of those on treatment who are virally suppressed. Household surveys provide population-level estimates to validate and complement routine program data for these targets.
Why use household survey data if routine program data already exists?
Because 95-95-95 and other goals are population-level targets, household surveys offer an independent way to estimate key indicators and validate and complement routine program data.
What laboratory measurements are highlighted in the opportunity?
The description highlights viral load testing, drug resistance, and other relevant biomarkers, along with specimen repositories that can support future testing as needs and assays evolve.
Can surveys include measurements beyond HIV?
Yes. The opportunity allows integrating related health measurements closely connected to HIV outcomes and public health planning, including tuberculosis, hepatitis, and syphilis.
Why integrate TB, hepatitis, or syphilis measurements into an HIV survey?
Combining surveillance can strengthen public health action and efficiency, help interpret co-infection burdens, identify overlapping risk patterns, and support planning for integrated service delivery.
What is CDC emphasizing about data quality and comparability?
The NOFO emphasizes standardized methods for interviews and laboratory work to produce high-quality datasets that can be compared across time and, where appropriate, across countries and regions.
Does the opportunity include capacity-building in the countries where surveys occur?
Yes. The NOFO explicitly aims to strengthen local survey capacity so that countries build systems and expertise to plan, implement, and analyze high-quality population surveys in-country, not just produce one-time estimates.
Are the resulting datasets expected to be publicly accessible?
Yes. A major priority is ensuring resulting data are publicly accessible to support transparency and broader scientific and programmatic use to improve HIV responses.
What are specimen repositories, and why are they mentioned?
Specimen repositories are collections of biological specimens retained for potential future testing and research. They are highlighted because they can support additional analyses as new questions emerge, new assays become available, or further validation is needed.
What is the activity category for this opportunity?
The activity category is health.
What is the CFDA number associated with this award?
The opportunity is listed under CFDA 93.067.
Who is eligible to apply?
Eligibility is described as broadly unrestricted (open to any type of entity), subject to any additional eligibility language in the full announcement.
What is the maximum award amount (award ceiling)?
The award ceiling is listed as $75,000,000.
How many awards did CDC expect to make?
CDC expected to make four awards.
When was the opportunity created?
The opportunity was created on June 14, 2018.
What was the original application closing date?
The original closing date was August 14, 2018.
How were applications required to be submitted?
Applications were required to be submitted electronically.
What time were applications due on the closing date?
Applications were due by 11:59 p.m. Eastern Time on the due date.
What is the core outcome CDC is trying to achieve through this funding?
The opportunity is structured to produce decision-ready HIV surveillance evidence, improve country capacity to generate that evidence, and make both data and specimens available in ways that can continue strengthening HIV programs over time.
What makes this opportunity different from funding that focuses only on case reporting?
Rather than relying on basic case counts, the surveys directly estimate prevalence and incidence and collect laboratory and interview measures of service reach, including viral suppression and biomarkers, to better assess real-world program impact.
What does "nationally and subnationally representative" imply for the survey outputs?
It implies the survey is designed to produce reliable estimates both for the country as a whole and for geographic or administrative areas within the country, supporting decision-making at national and local levels.
How will survey results be used by governments and partners?
The results are intended to provide evidence that can be used to adjust HIV strategies at both national and local levels, including assessing prevention and treatment coverage and monitoring progress toward major targets like 95-95-95.
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