Opportunity Information: Apply for PA 18 927
The grant opportunity "Innovative Technologies for HIV Behavioral and Social Science Research (R41/R42 Clinical Trial Optional)" (Funding Opportunity Number PA-18-927) is a discretionary National Institutes of Health (NIH) funding program designed specifically for small businesses applying through the Small Business Technology Transfer (STTR) mechanism. Its central purpose is to help small companies, working in partnership with a research institution, create and move forward new or adapted technologies that strengthen HIV prevention and HIV treatment efforts, with a clear emphasis on behavioral and social science research questions that align with the National Institute of Mental Health (NIMH) Division of AIDS Research priorities. In practical terms, the program is looking for technology-driven tools, platforms, or methods that can improve how HIV-related behaviors are understood, measured, predicted, or influenced, and how social and structural factors affecting HIV outcomes are studied and addressed.
Because it is an STTR opportunity, the intent is not just to support basic research, but to accelerate development toward products or usable research technologies that can be deployed in real-world HIV prevention or care contexts. Applications may propose the development of entirely new technologies or the application or adaptation of existing technologies to HIV behavioral and social science research. This can include innovations that support prevention and treatment across different populations and settings, such as tools that improve intervention delivery, enhance adherence support, enable better behavioral measurement, or help researchers and practitioners understand and respond to social drivers of risk and health outcomes. The listing notes "Clinical Trial Optional," meaning applicants may include a clinical trial if it is appropriate for the technology development and research plan, but proposing a trial is not required to be eligible.
The funding instrument is an NIH grant under the STTR phased structure: R41 is typically the early, feasibility and proof-of-concept phase, and R42 is the later, development and commercialization-ready phase. This structure is meant to move projects from concept to a more mature prototype or validated technology with a plausible path toward implementation or broader use. Although the source text does not provide specific award ceiling amounts or the number of expected awards, the emphasis is on technology development that advances NIMH's HIV-related mission within behavioral and social science domains, rather than purely biomedical product development without a behavioral or social science application.
Eligibility is limited to small businesses, consistent with STTR requirements. Non-U.S. (non-domestic) entities, including foreign institutions, are not eligible to apply directly, and non-U.S. components of U.S. organizations are also not eligible to apply. However, the announcement notes that "foreign components," as NIH defines them in its Grants Policy Statement, may be allowed in some cases, which generally means a U.S.-led project can include certain foreign-based elements if they are well-justified, clearly necessary for the project, and consistent with NIH policy. The opportunity is administered by NIH (CFDA 93.242), was created on 2018-09-19, and lists an original closing date of 2021-09-05, reflecting the posted timeline for that announcement cycle.Apply for PA 18 927
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Innovative Technologies for HIV Behavioral and Social Science Research (R41/R42 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
- This funding opportunity was created on 2018-09-19.
- Applicants must submit their applications by 2021-09-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Frequently Asked Questions (FAQs)
What is the name and funding opportunity number (FOA) for this grant?
The opportunity is titled "Innovative Technologies for HIV Behavioral and Social Science Research (R41/R42 Clinical Trial Optional)" and the Funding Opportunity Number is PA-18-927.
Which agency runs this funding program?
This is a National Institutes of Health (NIH) discretionary funding opportunity.
What NIH institute priorities does this opportunity emphasize?
The opportunity emphasizes behavioral and social science research questions aligned with the National Institute of Mental Health (NIMH) Division of AIDS Research priorities.
What is the main purpose of this STTR grant?
The central purpose is to help small businesses, in partnership with a research institution, create and advance new or adapted technologies that strengthen HIV prevention and HIV treatment efforts, with a clear emphasis on behavioral and social science research.
What kinds of projects are a good fit for this opportunity?
Projects that develop technology-driven tools, platforms, or methods that improve how HIV-related behaviors are understood, measured, predicted, or influenced, and/or that improve how social and structural factors affecting HIV outcomes are studied and addressed.
Does this program fund basic research, or is it aimed at product/technology development?
While research is involved, the intent is not just to support basic research. As an STTR opportunity, it is designed to accelerate development toward products or usable research technologies that can be deployed in real-world HIV prevention or care contexts.
Can applicants propose entirely new technologies, or must they adapt existing ones?
Either approach is allowed. Applications may propose development of entirely new technologies or the application/adaptation of existing technologies to HIV behavioral and social science research.
What are examples of the types of technology uses mentioned?
The description highlights innovations that could support prevention and treatment across populations and settings, such as tools that improve intervention delivery, enhance adherence support, enable better behavioral measurement, or help researchers and practitioners understand and respond to social drivers of risk and health outcomes.
Is a clinical trial required?
No. The FOA is labeled "Clinical Trial Optional," meaning a clinical trial may be included if appropriate for the technology development and research plan, but proposing a trial is not required for eligibility.
What funding mechanism does this opportunity use?
This opportunity uses the Small Business Technology Transfer (STTR) mechanism, with the NIH phased structure of R41 and R42.
What is the difference between R41 and R42 in this program?
R41 is typically the early phase focused on feasibility and proof of concept. R42 is the later phase aimed at further development toward a more mature prototype or validated technology with a plausible path toward implementation or broader use.
Who is eligible to apply?
Eligibility is limited to small businesses, consistent with STTR requirements, and the project is intended to be conducted in partnership with a research institution.
Are non-U.S. (foreign) organizations eligible to apply directly?
No. Non-U.S. (non-domestic) entities, including foreign institutions, are not eligible to apply directly.
Can a U.S. organization include non-U.S. components in its application?
Non-U.S. components of U.S. organizations are not eligible to apply. However, the announcement notes that "foreign components" (as defined by NIH in its Grants Policy Statement) may be allowed in some cases if well-justified, clearly necessary for the project, and consistent with NIH policy.
Does the opportunity focus on biomedical product development?
The emphasis is on technology development that advances NIMH's HIV-related mission within behavioral and social science domains, rather than purely biomedical product development without a behavioral or social science application.
Are award amounts, award ceilings, or the number of awards provided in the information given?
No. The provided information does not specify award ceiling amounts or the number of expected awards.
What is the CFDA number associated with this opportunity?
The opportunity is listed under CFDA 93.242.
When was this opportunity created, and what closing date is listed?
The opportunity was created on 2018-09-19 and lists an original closing date of 2021-09-05, reflecting the posted timeline for that announcement cycle.
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