Opportunity Information: Apply for RFA AA 20 013
The Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia funding opportunity (RFA-AA-20-013) is a National Institutes of Health program led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) within the U.S. Department of Health and Human Services. It supports collaborative, multi-project research efforts through the U01 cooperative agreement mechanism, with clinical trials allowed but not required ("Clinical Trial Optional"). The central goal is to renew and continue a coordinated research initiative focused on understanding the brain mechanisms that drive excessive alcohol drinking and other related traits and behaviors (phenotypes) that are associated with alcohol use disorder (AUD). In practical terms, this opportunity is designed to bring together teams that can integrate neuroscience approaches to explain how alcohol alters brain circuits and biology in ways that contribute to problematic drinking and AUD-relevant outcomes.
Because this is a cooperative agreement (rather than a standard research grant), funded projects are expected to operate as part of a broader INIA Consortium. That structure typically implies a higher level of coordination across awardees, shared goals, and active involvement by NIAAA program staff in steering and facilitating consortium activities. The emphasis on consortia-based work signals that applicants should be prepared to collaborate, harmonize methods when appropriate, and contribute to collective progress toward consortium-wide objectives around AUD neuroscience. The scientific scope highlighted in the notice points toward mechanistic brain research connected to excessive alcohol consumption and AUD-related phenotypes, which can include neural circuitry, molecular and cellular mechanisms, behavioral neuroscience, and translational approaches that link brain findings to clinically meaningful features of AUD.
The opportunity falls under the Health funding activity category and is associated with CFDA number 93.273. The eligibility list is broad and includes many types of domestic organizations that commonly apply to NIH programs: public and private institutions of higher education, state and local governments (including counties, cities/townships, special districts, and independent school districts), Native American tribal governments (federally recognized) and other tribal organizations, public housing authorities/Indian housing authorities, nonprofits with or without 501(c)(3) status (excluding higher education institutions in those nonprofit categories), for-profit organizations other than small businesses, small businesses, and additional eligible entities as described in the FOA's eligibility section. This wide eligibility is consistent with the program's intent to engage a diverse set of research-performing organizations capable of contributing to large-scale, collaborative neuroscience research.
From an administrative standpoint, the FOA was created on October 14, 2020, with an original closing date of May 26, 2021. The notice lists an expected number of awards of 16, indicating that NIAAA anticipated supporting a substantial set of U01 projects to form the consortium. The award ceiling is listed as 0, which generally indicates that a specific maximum amount was not stated in the summary field and would need to be confirmed in the full FOA details (NIH FOAs often define budgets in terms of allowable costs, project periods, and justification requirements rather than a single fixed cap in the summary). Overall, this opportunity is aimed at advancing a coordinated, integrative neuroscience understanding of why excessive drinking happens, how it becomes persistent or escalates, and how those underlying brain mechanisms relate to the broader clinical and behavioral landscape of AUD.Apply for RFA AA 20 013
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia (U01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
- This funding opportunity was created on Oct 14, 2020.
- Applicants must submit their applications by May 26, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 16 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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FAQs: Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia (RFA-AA-20-013)
What is the INIA Consortia funding opportunity (RFA-AA-20-013)?
The Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia funding opportunity (RFA-AA-20-013) is a National Institutes of Health (NIH) program led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) within the U.S. Department of Health and Human Services. It supports collaborative, multi-project research efforts that advance an integrative neuroscience understanding of alcohol use disorder (AUD) and excessive alcohol drinking.
Which federal agency and institute lead this program?
This is an NIH program led by NIAAA (the National Institute on Alcohol Abuse and Alcoholism), which is part of the U.S. Department of Health and Human Services.
What is the main scientific goal of this opportunity?
The central goal is to renew and continue a coordinated research initiative focused on understanding the brain mechanisms that drive excessive alcohol drinking and other AUD-related traits and behaviors (phenotypes). The program emphasizes mechanistic brain research that explains how alcohol alters brain circuits and biology in ways that contribute to problematic drinking and clinically meaningful AUD-relevant outcomes.
What type of award mechanism is used?
The opportunity uses the U01 cooperative agreement mechanism. This is different from a standard research grant because it is designed for projects that will operate with substantial coordination and active involvement from NIAAA program staff as part of a broader consortium effort.
What does it mean that this is a cooperative agreement (U01)?
A cooperative agreement indicates that funded projects are expected to operate as part of a larger INIA Consortium with shared goals and coordination across awardees. The description also notes active involvement by NIAAA program staff in steering and facilitating consortium activities. In practical terms, applicants should be prepared to collaborate, coordinate across teams, and contribute to consortium-wide objectives.
Are clinical trials allowed under this funding opportunity?
Yes. The FOA is listed as "Clinical Trial Optional," meaning clinical trials are allowed but not required.
Is a clinical trial required to apply?
No. Clinical trials are permitted but not mandatory under the "Clinical Trial Optional" designation.
What kinds of research topics fit within the scientific scope?
The scope points toward mechanistic neuroscience research connected to excessive alcohol consumption and AUD-related phenotypes. Examples of areas explicitly indicated include neural circuitry, molecular and cellular mechanisms, behavioral neuroscience, and translational approaches that connect brain findings to clinically meaningful features of AUD.
How does the consortium structure affect expectations for applicants?
Because awards operate as part of an INIA Consortium, funded teams are generally expected to coordinate across awardees, align and harmonize methods when appropriate, and contribute to collective progress toward shared consortium objectives focused on AUD neuroscience.
What is the funding activity category for this opportunity?
The opportunity falls under the Health funding activity category.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.273.
Who is eligible to apply?
The eligibility list is broad and includes many domestic organization types commonly eligible for NIH programs. Examples listed include public and private institutions of higher education; state and local governments (including counties, cities/townships, special districts, and independent school districts); federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and additional eligible entities as described in the FOA's eligibility section.
Are state and local government entities eligible?
Yes. The listed eligible applicants include state and local governments, including counties, cities/townships, special districts, and independent school districts.
Are tribal governments or tribal organizations eligible?
Yes. The eligibility list includes federally recognized Native American tribal governments as well as other tribal organizations.
Are nonprofits eligible to apply?
Yes. Nonprofits with or without 501(c)(3) status are included, with the note that the nonprofit categories referenced exclude higher education institutions in those nonprofit categories.
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations other than small businesses, and it also separately includes small businesses.
Are public housing authorities eligible?
Yes. The eligibility list includes public housing authorities/Indian housing authorities.
When was this FOA created?
The FOA was created on October 14, 2020.
What was the original closing date?
The original closing date listed is May 26, 2021.
How many awards were expected?
The notice lists an expected number of awards of 16, suggesting NIAAA anticipated supporting a substantial set of U01 projects to form the consortium.
Is there a maximum award amount (award ceiling)?
The award ceiling is listed as 0 in the summary. This generally indicates that a specific maximum amount was not stated in the summary field and would need to be confirmed in the full FOA details.
What does an award ceiling of 0 mean in this context?
An award ceiling shown as 0 typically signals that no single fixed maximum funding amount was provided in the summary information. The full FOA may describe budget expectations in other ways, such as allowable costs, project periods, and justification requirements, rather than a single stated cap.
What is the overall purpose of renewing and continuing INIA?
The overarching purpose is to advance a coordinated, integrative neuroscience understanding of why excessive drinking occurs, how it becomes persistent or escalates, and how the underlying brain mechanisms relate to the broader clinical and behavioral landscape of AUD.
What kinds of outcomes or phenotypes are emphasized?
The description highlights excessive alcohol drinking and other related traits and behaviors (phenotypes) associated with alcohol use disorder, with an emphasis on linking brain mechanisms to AUD-relevant outcomes.
Does this opportunity prioritize individual labs or collaborative teams?
The opportunity is designed to bring together teams and support collaborative, coordinated work through a consortium structure, rather than isolated single-investigator efforts.
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