NIGMS National and Regional Resources (R24 - Clinical Trial Not Allowed) | PAR 25 416

Opportunity Information: Apply for PAR 25 416

The NIGMS National and Regional Resources funding opportunity (R24, Clinical Trial Not Allowed; PAR-25-416) is a National Institutes of Health grant program designed to support shared research resources that serve a broad community of biomedical researchers across multiple states (regional) or nationwide (national). The main goal is to expand access to advanced capabilities that individual labs and even single institutions often cannot build or sustain alone. Funded resources are expected to function as open, high-impact hubs that provide investigators with access to state-of-the-art equipment, technologies, research tools, materials, organisms, software platforms, and/or specialized services, with the emphasis on reaching a substantial external user base rather than primarily serving a single local campus.

A key feature of this NOFO is that the resource must fall squarely within scientific and technical areas supported by NIGMS. In practice, that means the proposed facility or service should align with NIGMS program priorities and infrastructure needs rather than areas more typically led by other NIH Institutes and Centers. The program is also careful about overlap: it is meant to complement, not duplicate or replace, resources that are already funded by other NIH components or that should reasonably be covered by the applicant organization or host institution. Applicants are therefore expected to justify why the proposed resource fills a genuine gap at the regional or national level and how it will coordinate with existing infrastructure to avoid redundancy.

The opportunity supports resources that already exist as established facilities as well as resources that may be created through consolidation of existing local or regional capabilities. This is important because it allows institutions to strengthen impact by combining complementary cores, standardizing workflows, pooling expertise, and creating a unified access model for external users. Regardless of whether the resource is newly consolidated or long-standing, the expectation is that it will be operated at current best practices, maintained and upgraded over time, and run with a clear focus on quality, reliability, and broad usability.

Access and community engagement are central requirements. The resource is expected to actively publicize its capabilities and availability to the broader biomedical research community through a robust web presence and deliberate outreach activities. That typically implies clear, up-to-date online information about services, pricing or cost recovery (as applicable), request procedures, sample submission requirements, turnaround times, data delivery practices, and user policies. Beyond visibility, the resource is also expected to provide user training and ongoing support so that investigators can effectively use the tools or services, interpret outputs appropriately, and adopt best practices. This training component reinforces the idea that the award is not just purchasing instrumentation, but sustaining an expert-supported ecosystem that raises research capacity for many groups.

This is an R24 resource grant, and clinical trials are not allowed under this program. In other words, the award is intended to build and operate research resources, not to run clinical intervention studies. The resource can support research broadly, potentially including projects that touch many biomedical areas, but the funded activities under this award mechanism should remain focused on enabling and supporting research rather than conducting a clinical trial.

Eligibility is broad across U.S.-based organizations, reflecting the infrastructure-focused nature of the program. Eligible applicants include various levels of government (state, county, city/township, special districts), independent school districts, public and private institutions of higher education, federally recognized Native American tribal governments, public housing authorities/Indian housing authorities, Native American tribal organizations that are not federally recognized tribal governments, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), and small businesses. The NOFO also explicitly highlights several categories of institutions and organizations as eligible, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, eligible federal agencies, regional organizations, tribal governments that are not federally recognized, and U.S. territories or possessions.

At the same time, the program draws a hard line on foreign involvement for the applicant organization and project components. Non-domestic (non-U.S.) entities are not eligible to apply, non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined by NIH policy) are not allowed. This means the resource and the supported activities must be fully U.S.-based in both governance and execution.

Administratively, the opportunity is offered by NIH under the Health funding activity category (CFDA 93.859) as a discretionary grant. The funding opportunity was created on 2025-06-11, and the listed closing date is 2027-06-14. The posted data do not specify an award ceiling or the expected number of awards, so applicants typically need to refer to the full NOFO text and NIH budget guidance for details on allowable costs, project period expectations, and competitiveness norms.

Overall, this NOFO is aimed at building and sustaining high-value, broadly accessible biomedical research resources that can reliably serve many users beyond the host institution, stay technically current, provide strong training and support, and strengthen the research ecosystem in NIGMS-relevant areas without duplicating existing support structures.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIGMS National and Regional Resources (R24 - Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859.
• This funding opportunity was created on 2025-06-11.
• Applicants must submit their applications by 2027-06-14.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 25 416

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