Opportunity Information: Apply for RFA CA 17 016
The Resource Center for the Consortium for Pancreatic Ductal Adenocarcinoma (PDAC) Translational Studies (U24) funding opportunity (RFA-CA-17-016) is a National Institutes of Health (NIH), Department of Health and Human Services grant that supports the creation of a centralized Resource Center to serve a larger multi-project research Consortium focused on PDAC and, specifically, the tumor microenvironment. The driving scientific purpose is to accelerate translational studies that can inform and enable the design of new immunotherapy approaches and rational combination interventions for pancreatic ductal adenocarcinoma, a cancer type widely recognized for its resistance to many existing therapies and its highly complex, immunosuppressive microenvironment.
This award uses a cooperative agreement mechanism (U24), which generally means the project is expected to be collaborative and interactive, with substantial involvement from the funding agency compared to a typical investigator-initiated grant. In practical terms, the Resource Center is meant to function as shared infrastructure and coordination capacity for the Consortium rather than as a standalone laboratory project. The Resource Center would typically be responsible for enabling and harmonizing Consortium activities, such as organizing communication and governance, supporting shared resources or services, standardizing data and materials across participating sites, and facilitating efficient collaboration so that findings can be compared, integrated, and translated more effectively. The overall aim is to reduce fragmentation across projects and speed progress toward clinically relevant immunotherapy and combination strategies in PDAC.
The opportunity falls under the broad activity areas of education and health and is associated with CFDA numbers 93.395 and 93.396. The FOA anticipated making a single award (ExpectedAwards: 1), emphasizing that the intent was to stand up one central Resource Center to serve the full Consortium. The maximum award amount listed is an annual ceiling of $350,000, indicating a modest budget relative to large research centers and reinforcing the idea that the Resource Center role is enabling, integrative, and service-oriented rather than funding multiple large research aims on its own.
Eligibility is broad and includes a wide range of public and private entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories as listed); for-profit organizations (other than small businesses); and small businesses. This breadth suggests NIH was open to hosting the Resource Center at many kinds of institutions, as long as they could credibly deliver the coordination, infrastructure, and cross-institutional support the Consortium would require.
Key administrative details place the FOA in the 2016-2017 cycle: it was created on December 16, 2016, with an original closing date of March 7, 2017. The sponsor is NIH within HHS, and the category is discretionary funding. In summary, this FOA sought one awardee to build and operate a centralized Resource Center that would provide the organizational backbone and shared support functions for an NIH Consortium studying the PDAC tumor microenvironment, with the explicit translational objective of informing next-generation immunotherapy and combination treatment strategies for pancreatic cancer.Apply for RFA CA 17 016
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Resource Center for the Consortium for Pancreatic Ductal Adenocarcinoma (PDAC) Translational Studies (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.395, 93.396.
- This funding opportunity was created on Dec 16, 2016.
- Applicants must submit their applications by Mar 07, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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FAQs: Resource Center for the Consortium for PDAC Translational Studies (U24) (RFA-CA-17-016)
What is this funding opportunity?
This opportunity (RFA-CA-17-016) is an NIH (HHS) grant to create a centralized Resource Center for a larger, multi-project research Consortium focused on pancreatic ductal adenocarcinoma (PDAC), with a specific emphasis on the tumor microenvironment.
What is the main scientific purpose of the Resource Center?
The scientific purpose is to accelerate translational studies that can inform and enable the design of new immunotherapy approaches and rational combination interventions for PDAC, a cancer known for resistance to many existing therapies and for having a complex, immunosuppressive tumor microenvironment.
What does PDAC mean in this announcement?
PDAC refers to pancreatic ductal adenocarcinoma. In this FOA, PDAC is the disease focus for the Consortium and the Resource Center that supports it.
What is meant by a "Resource Center" in this FOA?
The Resource Center is intended to serve as centralized shared infrastructure and coordination capacity for the Consortium. It is described as an enabling, integrative, and service-oriented hub rather than a standalone laboratory project with multiple large independent research aims.
What kinds of activities would the Resource Center typically support?
Based on the FOA description, typical responsibilities include enabling and harmonizing Consortium activities by organizing communication and governance, supporting shared resources or services, standardizing data and materials across participating sites, and facilitating efficient collaboration so findings can be compared, integrated, and translated more effectively.
How does this FOA aim to improve Consortium research progress?
The Resource Center model is meant to reduce fragmentation across multiple projects and sites by providing shared coordination, standardization, and support functions, with the overall intent of speeding progress toward clinically relevant immunotherapy and combination strategies in PDAC.
What grant mechanism is used, and what does it imply?
This FOA uses a cooperative agreement mechanism (U24). A U24 generally implies a collaborative and interactive project with substantial involvement from the funding agency, compared with a typical investigator-initiated grant.
Is this intended to fund a standalone research lab?
No. The Resource Center is described as shared infrastructure and a coordination backbone for the Consortium, rather than a standalone lab project.
How many awards were anticipated under this FOA?
The FOA anticipated making a single award (ExpectedAwards: 1), reflecting an intent to stand up one central Resource Center to serve the full Consortium.
What is the maximum award amount?
The maximum award amount listed is an annual ceiling of $350,000.
What does the $350,000 annual ceiling suggest about the scope of work?
The stated ceiling suggests a modest budget relative to large research centers and reinforces that the Resource Center role is primarily enabling, integrative, and service-oriented (coordination, standardization, shared support), rather than supporting multiple large independent research aims.
Who is the sponsoring agency?
The sponsor is the National Institutes of Health (NIH) within the U.S. Department of Health and Human Services (HHS).
What type/category of funding is this?
The FOA is categorized as discretionary funding.
What activity areas does this opportunity fall under?
The opportunity falls under the broad activity areas of education and health.
What CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA numbers 93.395 and 93.396.
What types of organizations are eligible to apply?
Eligibility is broad. Eligible applicants include:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Other tribal organizations
- Public housing authorities/Indian housing authorities
- Nonprofit organizations with 501(c)(3) status (excluding institutions of higher education in those nonprofit categories as listed)
- Nonprofit organizations without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories as listed)
- For-profit organizations (other than small businesses)
- Small businesses
Does the FOA restrict eligibility to academic institutions only?
No. The eligibility list includes many public and private entity types, including governments, nonprofits, for-profits (other than small businesses), and small businesses, in addition to higher education institutions.
What does broad eligibility imply about the type of applicant NIH was willing to fund?
It implies NIH was open to hosting the Resource Center at many kinds of institutions, provided they could credibly deliver Consortium-wide coordination, infrastructure, standardization, and cross-institutional support.
What is the specific research focus within PDAC mentioned here?
The Consortium focus highlighted in this FOA is PDAC and, specifically, the tumor microenvironment, including its immunosuppressive characteristics and how that relates to developing immunotherapy and rational combination interventions.
What is the intended translational outcome of this Consortium and Resource Center?
The intended translational outcome is to inform and enable the design of next-generation immunotherapy approaches and rational combination treatment strategies for PDAC.
When was the FOA created, and what was the original closing date?
The FOA was created on December 16, 2016, and had an original closing date of March 7, 2017.
What timeframe does this FOA fall into?
Based on the administrative details provided, it falls within the 2016-2017 cycle.
Why does the FOA emphasize standardizing data and materials across sites?
The FOA description indicates the Resource Center should help standardize data and materials across participating sites so results can be compared, integrated, and translated more effectively across the Consortium.
What does "substantial involvement from the funding agency" mean in this context?
Because the mechanism is a U24 cooperative agreement, the FOA notes that the project is expected to be collaborative and interactive, with more agency involvement than in a typical investigator-initiated grant.
Is the goal to create multiple Resource Centers at different institutions?
No. The FOA anticipated a single award and describes standing up one central Resource Center to serve the entire Consortium.
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